ELISA Kit for Glycogen Synthase Kinase 3 Beta GSK3b
1995 Dec 21-28;378(6559):785-9. [PubMed:8524413] Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR: Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. 2021-03-04 Glycogen synthase kinase-3 (GSK3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase (see GYS1, 138570). Two isoforms, alpha (GSK3A; 606784 ) and beta, show a high degree of amino acid homology ( … 2019-03-29 Recent developments suggest an active role of glycogen synthase kinase 3 beta (GSK3 β) in various human cancers either as a tumor suppressor or as a tumor promoter. GSK3β is a Ser/Thr protein Protein target information for Glycogen synthase kinase-3 beta (human).
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer's disease. We report the characterization of a GSK3 inhibitor, AR-A014418, which inhibits GSK3 (IC50 = 104 +/- 27 nM), in an ATP-competitive manner (Ki = 38 nM) Se hela listan på de.wikipedia.org Glycogen synthase kinase 3 beta (Gsk3b) encodes a multifunctional serine/threonine protein kinase, which is ubiquitously expressed in organisms ranging from yeasts to mammals [1–3]. Modulated by serine and tyro-sine phosphorylation, Gsk3b is involved in many biolog-ical processes, such as energy metabolism, neuronal The Reperfusion Injury Salvage Kinase pathway (RISK) stands as one of the signal cascades that bestows cardioprotection through the activation of PI3K/Akt and inactivation of glycogen synthase kinase 3 beta (GSK3β) by phosphorylation of serine 9 (S9). 8 GSΚ3β plays an essential role in a multitude of cellular functions and undergoes complex regulation; the autophosphorylation of GSK3β on Sutherland C, Leighton IA, Cohen P: Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J. 1993 Nov 15;296 ( Pt 1):15-9.
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2021-02-20 NX_P49841 - GSK3B - Glycogen synthase kinase-3 beta - Function. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, … 2012-06-12 2013-10-25 Using human glycogen synthase kinase 3 beta (Gsk-3 beta) as bait in the yeast two-hybrid system, we identified a novel human dynamin-like protein IV (HdynIV). When the full-length cDNA of HdynIV was sequenced, it showed that HdynIV's carboxyl terminal lacks a proline-rich domain that can bind to Gsk-3 beta. Glycogen Synthase Kinase 3 (GSK3) was first purified classified as a kinase based on its ability to phosphorylate and inactivate Glycogen Synthase, acting as a regulator in Glycogen synthesis . However, Glycogen Synthase was thought to exist as early as the 1960s . This kinase … This dye is constituted of mixed bromine-substituted indigo and indirubin isomers. Among these, the new natural product 6-bromoindirubin and its synthetic, cell-permeable derivative, 6-bromoindirubin-3'-oxime (BIO), display remarkable selective inhibition of glycogen synthase kinase-3 (GSK-3).
on Tue Oct 22 12:49:34 UTC 2019
GSK3B - Glycogen Synthase Kinase-3 Beta. Looking for abbreviations of GSK3B? It is Glycogen Synthase Kinase-3 Beta. Glycogen Synthase Kinase-3 Beta listed as GSK3B. GSK3B A gene on chromosome 3q13.3 that encodes a serine-threonine kinase of the glycogen synthase kinase subfamily, which is involved in glycogen metabolism, proliferation, motility, survival, neuronal development and body pattern formation. View application images and datasheets for 981 anti Glycogen-Synthase-Kinase-3-Beta Antibody antibodies from 37 leading antibody suppliers, plus reviews and the top related antibodies
Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta .
Small-molecule GSK-3β inhibitors are currently undergoing clinical investigation. 2000-05-01 · Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase.
One of its isoforms, GSK-3β, acts as both a tumor suppressor and a proto-oncogene, depending on the downstream target (2). Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1.
380 ppm in percent
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TRAF6 function as a novel co-regulator of Wnt3a target genes
Pathway. hsa01521, EGFR tyrosine kinase inhibitor resistance Nov 3, 2011 Glycogen synthase kinase 3 (GSK-3) is an important drug target for C, O, Cα, C β) for the 25 GSK3 structures present in the protein data bank. Feb 17, 2016 (Click on the image to enlarge.) Before phosphorylation can be catalyzed by GSK -3, both the β-strand and α-helical domains must align in a Nov 27, 2014 GSK3 refers to two paralogs that are commonly referred to as isoforms, GSK3α and GSK3β. A theoretical analysis found that GSK3β has more When the Wnt pathway is stimulated, GSK-3 is inactivated, β-catenin builds up and Other Names, Glycogen synthase kinase 3α, Glycogen synthase kinase 3β Explore the GSK3 signaling pathway and find antibodies to detect some of its target proteins, including beta-catenin, GSK, CD324 (E-cadherin), and CD144 Dysregulation of the protein kinase glycogen synthase kinase 3 (GSK-3) has GSK-3α/β (Biosource) and β-catenin (BD Transduction Laboratories); liver GS Sep 1, 2004 GSK-3, as part of a multi-protein complex that contains proteins such as axin, presenilin and β-catenin, contains many additional target sites for Glycogen synthase kinase 3β (GSK3β) plays a key role in insulin and Wnt signaling, In Wnt signaling, GSK3β phosphorylates β-catenin, promoting its the catalytic residues in their active conformation, would be hard to maintain ( Fi Mar 28, 2014 Glycogen synthase kinase‑3 (GSK‑3) is a pleiotropic Zheng H, Li W, Wang Y, et al: Glycogen synthase kinase-3 beta regulates Snail and NX_P49841 - GSK3B - Glycogen synthase kinase-3 beta - Function.
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Abnormal regulation and expression of GSK3β is associated with an increased susceptibility towards bipolar disorder.