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found a mean T1 RT of 427 ± 159 ms and a mean T1 RC of 636 ± 189 ms. Multanen et al 2006-11-01 Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic. The most commonly used contrast agent for the dGEMRIC technique is Magnevist (Bayer Heathcare). Even though the contrast agent Magnevist has been approved for clinical use as an MRI contrast agent, the dGEMRIC technique itself is an off-label application. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a new imaging technique to estimate joint cartilage glycosaminoglycan content by T1-relaxation time measurements after penetration of the hydrophilic contrast agent Gd-DTPA2-.

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This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically verified cartilage changes (softening and fibrillations) in the medial or lateral femoral compartment, knee pain, and normal weight-bearing radiography were included. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is sensitive to the glycosaminoglycan content in cartilage that is lost early in the development of osteoarthritis (OA). Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint Background: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a validated technique for evaluating cartilage health in developmental dysplasia of the hip (DDH), which can be a helpful prognosticator for the response to surgical treatments.

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SCIENTIFIC ARTICLE Using the dGEMRIC technique to evaluate cartilage health in the presence of surgical hardware at 3T: comparison of inversion recovery and saturation recovery approaches 2012-10-01 · The dGEMRIC technique is based on the electrical polarity of gadolinium [Gd(DPTA) 2− ions] and glycosaminoglycans in the joint. After intravenous injection of the gadolinium, the Gd(DPTA) 2− ions diffuse into the joint, and subsequently distribute between the negatively charged glycosaminoglycan side chains of the cartilage in an inverse relationship 9 . Newer MRI cartilage mapping techniques such as T1 rho (ρ) and T2* have been performed in the hip without the need for any contrast, although it is unknown whether they are equivalent to dGEMRIC. Question/purpose: In this study, our purpose was to determine the correlation between the relaxation values of three cartilage mapping techniques, dGEMRIC, T1ρ, and T2*, in patients with DDH. @article{342e72fa-4c81-4f53-b7a2-63ac1ef24d30, abstract = {Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo.

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We tested two strategies to reduce metal artifact in dGEMRIC: (1) saturation recovery (SR) instead of inversion recovery (IR) and (2) applying the metal artifact reduction sequence (MARS), in a gadolinium-doped agarose gel phantom and in vivo with titanium hardware.

trastförstärkt MR (dGEMRIC), där man försöker *Compared to existing techniques for single tunnel ACL reconstruction. operative technique and preliminary. molekylär brosksammansättning, dGEMRIC (delayed Gadolinium-enhanced Parkinson's disease: Measurements with opto-electronic recording technique. dGEMRIC, or delayed gadolinium-enhanced MRI of cartilage is a technique that can be used quantitatively to assess glycosaminoglycan content of cartilage or qualitatively to asses the overall structures of cartilage. When the technique is adapted and applied to menisci it is called dGEMRIM.
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Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning) Biochemical validity of imaging techniques (X-ray, MRI, and dGEMRIC) in degenerative disc disease of the human cervical spine-an in vivo study. Bostelmann R(1), Bostelmann T(2), Nasaca A(2), Steiger HJ(2), Zaucke F(3), Schleich C(4). 2015-04-26 · Hence, the dGEMRIC technique holds promise for the development of new diagnostic and therapeutic procedures. However, because of the location of the hip joint deep within the body and due to the fairly thin cartilage layers that require high spatial resolution, the diagnosis of early hip joint cartilage alterations may be problematic. Background dGEMRIC (delayed Gadolinium Enhanced Magnetic Resonance Image of Cartilage) is a well-established technique for cartilage quality assessment in osteoarthritis at clinical field strengths.

The delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) technique is a well- established method for early assessment of cartilage quality in osteoarthritis.
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We examined the effect of stainless-steel and titanium hardware on dGEMRIC T 1 maps. We tested two strategies to reduce metal artifact in dGEMRIC: (1) saturation recovery (SR) instead of inversion recovery (IR) and (2) applying the metal artifact reduction sequence (MARS), in a gadolinium-doped agarose gel phantom and in vivo with titanium hardware. In the dGEMRIC technique, the negatively charged contrast agent Gd-DTPA 2− (Magnevist, Berlex, NJ) is injected intravenously and diffuses into articular cartilage, with a final concentration inversely proportional to the cartilage GAG concentration 7. The relative GAG concentration is estimated by measuring the T1 values after penetration of The two main 3D techniques that are considered for T1 quantification in dGEMRIC today are 3D-Look-Locker (3D-LL) [ 11, 20] and 3D-variable flip angle (3D-VFA) [ 22, 23 ]. The 3D Look-Locker technique has been validated against the traditional inversion recovery technique.